The FTSE 100 moved 0.71%, or 54.24 factors, decrease to complete at 7,588.48.
Michael Hewson, chief market analyst at CMC Markets UK mentioned: “Pharmaceutical giant AstraZeneca is acting as the biggest drag on the FTSE 100 on reports it is mulling a separate listing in Hong Kong as it looks to spin off its China business.
“Mining stocks are weaker on the back of disappointment that Chinese authorities haven’t weighed in on any new stimulus measures yet, with the likes of Rio Tinto and Glencore slightly lower.”
The different main European markets carried out equally, whereas the US markets had been shut for the Juneteenth vacation.
“Becalmed by an empty calendar, markets have drifted lower, though with Powell testifying later in the week traders shouldn’t assume the dip buyers will immediately step in tomorrow.”
Germany’s Dax index fell by 0.96% and the Cac 40 closed down 1.01%.
Meanwhile, sterling slipped because it misplaced momentum following its strongest week towards the greenback to this point this yr, regardless of the rise in gilt yields.
The pound was down 0.17% to 1.279 US {dollars} and had dropped 0.03% to 1.171 euros at market shut in London.
In firm news, medication big AstraZeneca dropped in worth after reviews it’s taking a look at plans to spin off its Chinese companies to guard it from geopolitical rigidity.
Citing individuals accustomed to the scenario, the Financial Times mentioned the British-Swedish medication big has been in talks with bankers for a number of months.
Shares within the firm closed 142p decrease at 11,646p in consequence.
Fashion retailer Next was one of many prime performers after it lifted its gross sales and revenue steering for the yr.
Next reported better-than-expected gross sales over the previous seven weeks, linking the 9.3% soar in full-price gross sales to hotter climate and continued wage will increase.
Shares in Next had been 304p increased at 6,742p on the shut of buying and selling on Monday.
Rivals together with Frasers Group and Primark proprietor Associated British Foods had been additionally lifted increased in consequence.
The worth of oil edged decrease amid uncertainties over demand in China and the prospect of any stimulus measures within the nation.
A barrel of Brent crude fell by 0.68% to 76.09 US {dollars} on the time markets had been closing in London.
The largest risers within the FTSE 100 had been Next, up 304p at 6,742p, Frasers Group, up 15p at 712p, Standard Chartered, up 12.6p at 687.8p, Rolls-Royce, up 2.6p at 153.8p, and Entain, up 16.5p at 1,237.5p.
The largest fallers of the session had been Spirax-Sarco, down 755p at 10,360p, Ocado Group, down 27p at 434.9p, Croda International, down 160p at 5,370p, Johnson Matthey, down 47.5p at 1,692.5p, and Weir Group, down 48p at 1,764.5p.